The layoffs were necessary to combat rising costs at the mine, Anglo American said in a statement. The mine sits high in the Andes but on the outskirts of the capital city of Santiago, well south of the majority of the country's copper deposits.
"The future viability of Los Bronces requires an adjustment in the way we're organized, how we work and the technology that we use, in order to boost our efficiency and productivity," the miner said in the statement.
The mine's Union #2 staged a temporary walk-off ahead of the announcement, and said in a statement it was considering further labor action.
Several other miners in Chile, including top copper producer Codelco, are also overhauling mines and strategies as they seek to boost productivity amid increasing demand for the red metal but sometimes declining ore grades at the country's aging deposits.